比沙可啶是国外五十年代末上市的优良缓泻药,通过与肠粘膜直接接触刺激其感觉神经末梢而增强肠反射性蠕动,导致排便。比沙可啶普通片有继发性腹泻作用,因此,我们研制了结肠定位给药比沙可啶速释片,其优点是当药物到达特定部位结肠时,比沙可啶自片中释出,直接作用于结肠,没有继发性腹泻作用。现将本品的研制总结如下。 Bisacodyl is an excellent laxative that is marketed abroad in the late fifties to stimulate bowel reflex motility by direct contact with the intestinal mucosa to sensory nerve endings, leading to defecation. Bisacodyl ordinary tablets have secondary diarrhea, therefore, we developed a colon-administered bisacodyl immediate release tablets, its advantage is that when the drug reaches a specific part of the colon, bisacodyl released from the film, a direct role In the colon, there is no secondary diarrhea. Now the product development is summarized as follows.