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采用间接标记方法，通过对砹（２１１Ａｔ）苯甲酸中间体，制得２１１Ａｔ与单克隆抗体３Ｈ１１和Ｆａｂ片段的偶联物，其放化产率分别为３０％和３５％．２１１Ａｔ－３Ｈ１１和２１１Ａｔ－３Ｈ１１Ｆａｂ在体外稳定，对Ｍ８５人胃癌细胞具有明显的特异免疫结合和杀伤作用．核素前体掺入法的初步研究结果表明，２１１Ａｔ－３Ｈ１１和２１１Ａｔ－３Ｈ１１Ｆａｂ是通过对癌细胞ＤＮＡ和ＲＮＡ合成的抑制，特别是合成ＲＮＡ的抑制杀伤癌细胞的
The conjugates of 211At with the monoclonal antibody 3H11 and Fab fragments were prepared by indirect labeling method on the 211At benzoic acid intermediate. The radiochemical yields were 30% and 35%, respectively. 211At-3H11 and 211At-3H11Fab were stable in vitro and had obvious specific immunological binding and killing effect on M85 human gastric cancer cells. The preliminary results of the nuclear precursor incorporation assay showed that the 211At-3H11 and 211At-3H11Fab were able to inhibit cancer cell DNA and RNA synthesis, especially by inhibiting the synthesis of RNA.