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目的探讨盐酸替罗非班联合PCI对急性心肌梗死(AMI)患者血清MIF、IL-10的影响。方法将78例AMI患者随机分为治疗及对照组,均予常规溶栓及PCI治疗,治疗组加用盐酸替罗非班,首先10.0μg/kg静脉推注,然后以0.15μg/(kg·min)持续静脉滴注24 h。ELISA法检测各组治疗前后血清MIF、IL-10水平。并检测各组心功能各项指标。结果两组患者治疗后血清MIF水平均下降、IL-10水平均升高(P<0.05),心功能亦明显改善,但治疗组更为显著(P<0.05),且其总有效率显著高于对照组(P<0.05)。结论盐酸替罗非班可能通过调节抗炎反应平衡,改善AMI介入治疗患者的心功能,疗效满意。
Objective To investigate the effect of tirofiban hydrochloride combined with PCI on serum MIF and IL-10 in patients with acute myocardial infarction (AMI). Methods 78 AMI patients were randomly divided into treatment group and control group. All patients were treated with conventional thrombolysis and PCI. Tirofiban hydrochloride was used in the treatment group, min) for 24 h. Serum MIF and IL-10 levels were measured by ELISA before and after treatment. The indexes of cardiac function in each group were detected. Results After treatment, the levels of serum MIF, the level of IL-10 in both groups were significantly increased (P <0.05), and the cardiac function was also improved. However, the treatment group was more significant (P <0.05) and the total effective rate was significantly higher In the control group (P <0.05). Conclusion Tirofiban Hydrochloride may improve the cardiac function of AMI interventional therapy patients by adjusting the balance of anti-inflammatory response and the curative effect is satisfactory.