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Behcet氏病是一难以治疗的全身复发性炎性疾病。 Behcet氏病的组织病理学特征是血管炎症产生的急性渗出性改变,即白细胞漏出和血栓形成。一些研究表明,Behcet氏病存在体液免疫和细胞免疫的异常,中性白细胞活化作用的增强可能与免疫异常有关。报告指出合并有B细胞活化作用增加,可导致抑制中性白细胞活动的功能受损。目前,Behcet氏病的确切病因仍不清楚,本文作者对Behcet氏病的免疫学研究进展和近年的病因学研究进行了详述。
Behcet’s disease is a refractory systemic recurrent inflammatory disease. Histopathological features of Behcet’s disease are acute exudative changes in vascular inflammation, leukocyte leakage and thrombosis. Some studies have shown that there is abnormal humoral and cellular immunity in Behcet’s disease. The enhancement of neutrophil activation may be related to immune abnormalities. The report pointed out that the combination of B cell activation increased, can lead to inhibition of neutrophil function impaired. At present, the exact cause of Behcet’s disease remains unclear. The authors described the immunological progress of Behcet’s disease and the recent etiological studies.