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利用吡啶类多齿配体合成了1例双核锌配合物[Zn2L(OAc)2(CH3OH)4](Cl O4)2,其中L为4,4’-二[N,N-二(吡啶-2-甲基)]氨基二苯甲烷.运用元素分析、红外光谱表征该配合物并解析了其单晶结构,单晶结构表明,每个Zn中心均为六配位的畸变八面体构型;多种光谱方法表征发现配合物表现出了较强的化学核酸酶活性和BSA键合能力,MTT实验测定了该配合物对体外He La、MCF-7、RL952肿瘤细胞生长的抑制能力,结果表明其对He La细胞的增殖有明显的抑制作用.
One dinuclear zinc complex [Zn2L (OAc) 2 (CH3OH) 4] (ClO4) 2 was synthesized by using pyridine polydentate ligands, where L is 4,4’-bis [N, 2-methyl)] aminodiphenylmethane.The crystal structure of the complex was characterized by elemental analysis and infrared spectroscopy. The single crystal structure showed that each Zn center was a hexacoordinated distorted octahedron. A variety of spectroscopic methods showed that the complexes showed strong chemical nuclease activity and BSA binding ability. MTT assay was used to determine the ability of the complexes to inhibit the growth of He La, MCF-7 and RL952 tumor cells in vitro. The results showed that The He La cell proliferation was significantly inhibited.