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为探讨脂蛋白（a）高度致动脉粥样硬化作用的可能机制，本文通过体外CU2+氧化法进行了低密度脂蛋白和脂蛋白（a）的氧化，并利用细胞计数及氚标胸腺密啶脱氧核苷掺入法，比较观察了天然和氧化的脂蛋白（a）及低密度脂蛋白对培养的兔主动脉平滑肌细胞增殖的影响。结果发现，在相同氧化时间内脂蛋白（a）对Cu2+的氧化敏感性较低密度脂蛋白低；氧化后的脂蛋白（a）和低密度脂蛋白均可明显促进平滑肌细胞增殖使DNA合成增加（P＜0．01），且其作用较相应的天然脂蛋白大（P＜0．05．P＜0．01）、此结果提示：脂蛋白（a）经氧化后促进平滑肌细胞增殖可能是其致动脉粥样硬化的机制之一。
In order to explore the possible mechanism of the high level of atherogenic activity of lipoprotein (a), we oxidized low density lipoprotein and lipoprotein (a) by CU2 + oxidation method in vitro. Cytometry and tritiated thymidine deoxy Nucleoside incorporation method was used to compare the effects of native and oxidized lipoprotein (a) and low density lipoprotein on the proliferation of cultured rabbit aortic smooth muscle cells. The results showed that in the same oxidation time, the sensitivity of lipoprotein (a) to Cu2 + was lower than that of low-density lipoprotein. Both oxidized lipoprotein (a) and low-density lipoprotein could significantly promote the proliferation of smooth muscle cells and increase the DNA synthesis (P <0.01), and its effect was greater than the corresponding native lipoprotein (P <0.05.P <0.01). The results suggest that the lipoprotein (a) may promote the proliferation of smooth muscle cells after oxidation It is one of the mechanisms that contributes to atherosclerosis.