Dracaenoside A and B, New C-22 Steroidal Lactone Glycosides from the Stem of Dracaena cochinchinensi

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Two new C-22 steroidal lactone glycosides, named dracaenoside A and B were isolated from the methanol extract of the fresh stem of Dracaena cochinchinensis. Their structures were established as (20S)3b,14a,16b-trihydroxy pregn-5-ene-22-carboxylic acid (22,16)-lactone 3-O-a- L-rhamnopyranosyl (1→2)[ a-L-rhamnopyranosyl (1→4)]-b-D-glucopyranoside and (20S)3b, 14a, 16b-trihydroxy pregn-5-ene-22-carboxylic acid (22,16)-lactone 3-O-a-L-rhamnopyranosyl (1→2) [b-D-glucopyranosyl(1→3)]-b-D-glucopyranoside by means of 2D NMR spectral and chemical methods. It is the first time that steroidal lactone glycosides were isolated from the genus Dracaena. Two new C-22 steroidal lactone glycosides, named dracaenoside A and B were isolated from the methanol extract of the fresh stem of Dracaena cochinchinensis. Their structures were established as (20S) 3b, 14a, 16b-trihydroxy pregn-5-ene-22 -carboxylic acid (22,16) -lactone 3-Oa- L-rhamnopyranosyl (1 → 2) [aL-rhamnopyranosyl (1 → 4)] - bD-glucopyranoside and (20S) 3b, 14a, 16b-trihydroxy pregn- 5 -ene-22-carboxylic acid (22,16) -lactone 3-OaL-rhamnopyranosyl (1 → 2) [bD-glucopyranosyl (1 → 3)] - bD-glucopyranoside by means of 2D NMR spectral and chemical methods. the first time that steroidal lactone glycosides were isolated from the genus Dracaena.
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