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目的探讨扩散张量成像(diffusion tensor imaging,DTI)在早期放射性脑损伤中的应用价值。方法23例鼻咽癌放疗后常规MR表现正常者和28例健康正常人均做DTI,在双侧颞叶脑白质区域测量各向同性扩散张量(ADCiso)值和各向异性指数值。结果鼻咽癌放疗组ADCiso值(644.08±56.80)×10-6mm2/s,部分各向异性(FA)值0.394±0.074、相对各向异性(RA)值0.344±0.075及1减容积比(1-VR)值0.182±0.072均比正常对照组各值降低,与正常对照组比较差异有显著性意义(P<0.05)。结论DTI能探测到鼻咽癌放疗后常规脑MR表现所不能显示的改变,对放射性脑损伤的早期诊断提供了一种新的影像学诊断手段。
Objective To investigate the value of diffusion tensor imaging (DTI) in early radiation brain injury. Methods Twenty-three normal nasopharyngeal carcinoma patients with normal MR after radiotherapy and 28 normal healthy persons underwent DTI. ADCiso and anisotropy indices were measured in bilateral temporal white matter regions. Results ADCiso value (644.08 ± 56.80) × 10-6mm2 / s, partial anisotropy (FA) value of 0.394 ± 0.074, relative anisotropy (RA) value of 0.344 ± 0.075 and volume reduction ratio of 1 -VR) values of 0.182 ± 0.072 were lower than the normal control group, the difference was significant (P <0.05) compared with the normal control group. Conclusion DTI can detect the change of routine brain MR manifestations after nasopharyngeal carcinoma radiotherapy and provide a new imaging diagnostic tool for the early diagnosis of radiation brain injury.