糖尿病酮症酸中毒为糖尿病控制不良导致的一种需要急诊治疗的并发症,是由于胰岛素不足及升糖激素不适当升高引起糖、脂肪和蛋白质代谢紊乱,以至水、电解质和酸碱平衡失调,以高血糖、高血酮和代谢性酸中毒为主要表现的临床综合征,迄今为止,有较多的报道提示糖尿病酮症酸中毒患者血液存在高凝状态,或血栓形成等,近年来有研究表明血管内皮细胞的损伤在这一病理生理学过程中可能起了关键作用。本文将对这一观点进行探讨。 Diabetic ketoacidosis is a complication of emergency treatment due to poorly controlled diabetes due to disorders of glucose, fat and protein metabolism caused by inadequate insulin and inappropriately elevated glucocorticoids, disorders of water, electrolyte, and acid-base balance , With high blood sugar, high blood ketone and metabolic acidosis as the main clinical syndrome, so far, there are more reports suggest that patients with diabetic ketoacidosis hypercoagulable state of blood, or thrombosis, in recent years have Studies have shown that the damage of vascular endothelial cells may play a key role in this pathophysiological process. This article will explore this point of view.