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播散性念珠菌病是一种严重的感染性疾病.急性播散性念珠菌病可出现脓毒症状,导致肌痛、眼及皮肤的损害;慢性播散性念珠菌病可致肝、肾等受累脏器功能逐渐衰竭.病死率高达50%.该病主要发生于血液系统恶性肿瘤患者的治疗过程中;由于强化的抗癌疗法和大剂量抗生素的应用,播散性念珠菌病的发病率逐渐增高.以往规范的治疗是通过静脉给予两性霉素B和5-氟胞嘧啶,这一疗法副作用大,花费昂贵,且只有50%～70%的患者有效.本文的目的在于评价氟康唑(flu-conazole)治疗播散性念珠菌病的安全性和疗效.
Disseminated candidiasis is a serious infectious disease.Acute disseminated candidiasis can occur sepsis symptoms, resulting in muscle pain, eye and skin damage; chronic disseminated candidiasis can cause liver and kidney And other organs affected by the gradual exhaustion failure mortality as high as 50% of the disease occurs mainly in patients with hematological malignancies in the course of treatment; due to intensive anti-cancer therapy and the application of high doses of antibiotics, the incidence of disseminated candidiasis The rate of gradual increase in the past normative treatment of intravenous amphotericin B and 5-fluorocytosine, this treatment side effects, expensive, and only 50% to 70% of patients effective.The purpose of this paper is to evaluate fluconazole Safety and efficacy of flu-conazole in the treatment of disseminated candidiasis.