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目的了解孕晚期孕妇与新生儿血清25(OH)D水平。方法选取2016年在丽水市妇幼保健院分娩的单胎孕妇及其新生儿各600人为研究对象,通过问卷调查收集基本信息,检测孕妇分娩前静脉血及新生儿脐血25(OH)D水平。结果孕妇分娩前25(OH)D平均水平为(36.25±14.92)nmol/L,其中451人维生素D缺乏,占75.16%;新生儿25(OH)D平均水平为(29.59±16.13)nmol/L,其中495人维生素D缺乏,占82.50%。孕妇分娩前25(OH)D水平和新生儿25(OH)D水平呈正相关(r=0.892,P<0.05)。孕期常规剂量补充维生素D(400 IU/d)的孕妇25(OH)D水平高于未补充者(P<0.05);孕妇血清25(OH)D水平受季节的影响,夏季最高,冬季最低(P<0.05)。不同居住地、文化程度、孕期阳光暴露时间的孕妇25(OH)D水平差异均无统计学意义(P>0.05)。结论孕妇维生素D水平偏低,且有季节性差异;孕妇维生素D水平对新生儿维生素D水平有直接影响。
Objective To understand the serum levels of 25 (OH) D in pregnant women and newborns in the third trimester of pregnancy. Methods A total of 600 singleton pregnant women and their newborns delivered in Lishui Maternal and Child Health Care Hospital in 2016 were selected as research objects. Basic information was collected by questionnaire survey to detect the levels of venous blood and neonatal umbilical blood 25 (OH) D before delivery. Results The average level of 25 (OH) D before delivery in pregnant women was (36.25 ± 14.92) nmol / L, of which 451 were vitamin D deficient, accounting for 75.16%. The mean neonatal 25 (OH) D was (29.59 ± 16.13) , Of which 495 were vitamin D deficient, accounting for 82.50%. The level of 25 (OH) D before delivery in pregnant women was positively correlated with the 25 (OH) D level in newborns (r = 0.892, P <0.05). The 25 (OH) D level of pregnant women with routine dose of vitamin D (400 IU / d) during pregnancy was higher than that of those without serum supplementation (P <0.05). The level of 25 (OH) D in pregnant women was influenced by the seasons, P <0.05). There were no significant differences in the levels of 25 (OH) D in pregnant women with different places of residence, educational level and duration of sunshine during pregnancy (P> 0.05). Conclusions The level of vitamin D in pregnant women is low and there are seasonal differences. The level of vitamin D in pregnant women has a direct impact on the vitamin D level in newborns.