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目的:探讨胚胎经历二次冻融后移植对临床妊娠结局的可能影响。方法:回顾分析2012年6月至2014年12月在河南省人民医院(郑州大学人民医院)生殖医学研究所接受二次冻融周期复融囊胚移植的患者资料,随机选取同期进行常规单次冻融周期囊胚移植的患者作为对照组。比较两组患者的一般情况、种植率、临床妊娠率、异位妊娠率、流产率、多胎率、活产率、足月产率、新生儿情况等。结果:二次冻融组和对照组的临床妊娠率比较,差异有统计学意义(47.18%vs 71.83%,P=0.002);异位妊娠率、流产率、多胎率、足月产率比较,差异无统计学意义。出生婴儿未发现畸形。结论:二次冻融囊胚周期与单次冻融囊胚周期相比,临床妊娠率显著下降,认为多次冻融可能影响胚胎发育潜能。
Objective: To investigate the possible effect of embryo implantation after secondary freeze-thaw cycles on clinical pregnancy outcome. Methods: The data of patients who underwent secondary freeze-thaw cycles of reconstructive blastocyst transplantation at the Reproductive Medicine Institute of Henan Provincial People’s Hospital (People’s Hospital of Zhengzhou University) from June 2012 to December 2014 were retrospectively analyzed. Patients with frozen-thawed cycle blastocyst transplantation served as controls. The general situation, implantation rate, clinical pregnancy rate, ectopic pregnancy rate, miscarriage rate, multiple birth rate, live birth rate, full-term birth rate and neonatal condition were compared between the two groups. Results: The clinical pregnancy rates of secondary freeze-thaw and control groups were statistically significant (47.18% vs 71.83%, P = 0.002). The rates of ectopic pregnancy, miscarriage, multiple births and full-term births were significantly different The difference was not statistically significant. No abnormalities were found in babies born. CONCLUSION: The clinical pregnancy rate of secondary frozen-thawed blastocysts is significantly lower than that of single frozen-thawed blastocysts. It is considered that multiple freeze-thaw cycles may affect the embryonic development potential.