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运用大鼠乙酸慢性胃溃疡模型采用中药健脾益气方,观察治疗7d及21d后溃疡指数,溃疡抑制率及血清脂质过氧化物（LPO）和NO_3~-/NO_2~-含量变化。结果显示:中药治疗组溃疡指数、血清LPO含量显著低于模型组（P<0.01 ）,溃疡抑制率及血清NO_3~-/NO_2~-含量显著高于模型组（P<0.01 ）,与雷尼替丁组相比溃疡指数、血清LPO含量无统计学差异,但溃疡抑制率及血清NO_3~-/NO_2~-含量高于雷尼特丁组。模型组溃疡指数、血清LPO含量显著高于正常对照组（P<0.01 ）。而血清NO_3~-/NO_2~-含量则低于正常对照组（P<0.01）。提示中药健脾益气方能明显促进乙酸慢性胃溃疡愈合,其疗效与抑制脂质过氧化反应,诱导或提高血清NO合成有关。说明健脾益气方有胃粘膜保护作用。
The rat model of chronic gastric ulcer was used to observe the changes of ulcer index, ulcer inhibition rate, serum lipid peroxidation (LPO) and NO_3~-/NO_2~-increase after 7 days and 21 days. The results showed that the ulcer index and serum LPO content in the Chinese medicine treatment group were significantly lower than those in the model group (P<0.01), and the ulcer inhibition rate and serum NO_3~-/NO_2~- were significantly higher than those in the model group (P<0.01). There was no significant difference in the ulcer index and serum LPO content between the tetidine group, but the ulcer inhibition rate and serum NO_3~-/NO_2~- were higher than that of the ranitidine group. The ulcer index and serum LPO content in the model group were significantly higher than those in the normal control group (P<0.01). The content of serum NO_3~-/NO_2~- was lower than that of normal control group (P<0.01). The traditional Chinese medicine Jianpiyiqi can obviously promote the healing of chronic gastric ulcer of acetic acid, and the curative effect is related to the inhibition of lipid peroxidation and the induction or enhancement of serum NO synthesis. It shows that Spleen and Qi has protective effects on gastric mucosa.