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目的探讨不同临床分期的大肠癌患者外周血T1和T2淋巴细胞的变化规律。方法连续采集20例大肠癌患者初诊时外周血,以20例良性疾病患者外周血作为对照。应用胞内因子检测法检测T1及T2的比率。结果大肠癌患者外周血T1比率为(36±11)%,T2比率为3·3(1·9)%,均明显低于对照组[(46±12)%、4·1(3·1)%](P<0·05)。肿瘤直径≥5cm患者的T1低于肿瘤直径<5cm患者[(31±11)%比(40±10)%,P=0·064];低分化癌患者的T1低于高、中分化癌患者[(28±10)%比(38±11)%,P=0·072];有淋巴结转移患者的T1明显低于无淋巴结转移患者[(31±10)%比(41±10)%,P<0·05];Ⅲ、Ⅳ期患者的T1明显低于Ⅰ、Ⅱ期患者[(31±10)%比(41±10)%,P<0·05]。结论大肠癌患者外周血T1和T2比率显著降低。T1可能是判断大肠癌转移和预后的新指标。
Objective To investigate the changes of peripheral blood T1 and T2 lymphocytes in patients with different clinical stages of colorectal cancer. Methods Twenty consecutive patients with colorectal cancer were enrolled in this study. Peripheral blood was collected from 20 patients with benign disease. The intracellular factor test was used to detect the ratio of T1 and T2. Results The rate of T1 in the peripheral blood of patients with colorectal cancer was (36 ± 11)% and that of T2 was 3.3% (1.9%), which were significantly lower than those in the control group [(46 ± 12)%, 4.1 )%] (P <0 · 05). The T1 of tumor with diameter> = 5cm was lower than that of tumor with diameter <5cm [(31 ± 11)% vs (40 ± 10)%, P = 0 · 064] (31 ± 10)% (41 ± 10)% in the patients with lymph node metastasis, compared with those in patients without lymph node metastasis (28 ± 10% vs 38 ± 11%, P = 0 · 072) P <0.05]. The T1 of patients in stage Ⅲ and Ⅳ was significantly lower than that of patients in stage Ⅰ and Ⅱ [(31 ± 10)% vs (41 ± 10)%, P <0.05). Conclusion The rates of T1 and T2 in peripheral blood of patients with colorectal cancer are significantly lower. T1 may be a new indicator of metastasis and prognosis of colorectal cancer.