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采用ABC免疫组织化学方法对41例胃癌组织,66例正常胃和良性病变胃组织内癌胚抗原表达作了研究。结果显示;胃癌组织内癌胚抗原(CEA)的表达程度明显强于正常胃和良性病变胃组织;前者CEA的分布形式多呈胞浆型和间质型,而后者则呈腔缘型和膜型。同时表明组织内CEA的分布形式与肿瘤细胞的生长方式和浸润深度有关。作者认为组织内CEA的表达状况与胃癌细胞生物学行为有关,其在组织内的分布形式较其含量更为重要,相同组织学类型CEA亦可有不同的分布形式。
ABC immunohistochemical method was used to study the expression of carcinoembryonic antigen in gastric tissues from 41 cases of gastric cancer and 66 cases of normal gastric and benign lesions. The results showed that the expression of carcinoembryonic antigen (CEA) in gastric cancer tissue was significantly stronger than that in normal stomach and benign lesions. The distribution of CEA in the former was mostly cytoplasmic and interstitial, while that of the latter was luminal and membrane. type. At the same time, the distribution pattern of CEA in tissues is related to the growth pattern and depth of invasion of tumor cells. The authors believe that the expression of CEA in tissues is related to the biological behavior of gastric cancer cells, and its distribution pattern in tissues is more important than its content. CEA of the same histological type may also have different distribution forms.