论文部分内容阅读
目的:探讨中国人冠心病与凝血因子VII(FVII)基因多态性的相关性。方法:利用PCR技术对河南地区260例冠心病患者进行FVII基因del(-323)ins多态性的检测和分析,并与河南地区的健康人群对照进行比较,分析其多态性与冠心病遗传因素之间的相关性。结果:冠心病患者FVII基因del(-323)ins多态性的基因型频率和等位基因频率与对照组相比无明显差异。结论:FVII基因del(-323)ins多态性可能不是中国人群冠心病发病的遗传学危险因素。
Objective: To investigate the association between coronary heart disease and coagulation factor VII (FVII) gene polymorphisms in Chinese. Methods: PCR was used to detect and analyze the FVII gene del (-323) ins polymorphism in 260 cases of CHD patients in Henan Province. The polymorphisms were compared with those of healthy people in Henan Province. Correlation between factors. Results: There was no significant difference in genotype frequency and allele frequency between FVII gene del (-323) ins polymorphism and control group in patients with coronary heart disease. Conclusion: The FVII gene del (-323) ins polymorphism may not be a genetic risk factor for coronary heart disease in Chinese population.