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已知环孢菌素(cyclosporine)有明显的肾毒性,然而,环孢菌素相关性高血压(CAH)的发生率明显高于其肾毒性,究其机理尚未明,有认为CAH可能继发于钠潴留引起的中心容量扩大。本文旨在评价口服环孢菌素对饮食的慢性调节和急性扩容的肾排泄反应的影响。方法分为8天的慢性饮食研究和急性盐水扩容研究两部分,均在16～21kg 的蒙古狗中进行,所有狗配对喂养,每天给予恒定食物,允许自由饮水。实验组7只,口服环孢菌素20mg/kg/d;对照组6只,每天给予环孢菌素赋形剂。慢性研究:测定服药前及服药8天后的24小时钠分泌量、血浆肾素活性(PRA)、醛固酮(Aldo)、内皮素(ET)和心房利钠因子(ANF)。急性研究:在60分钟内静脉注入占体重10%的
Cyclosporine is known to have significant nephrotoxicity. However, the incidence of cyclosporine-related hypertension (CAH) is significantly higher than that of nephrotoxicity. The mechanism of such cyclosporine remains unclear. It is thought that CAH may be secondary Central retention caused by sodium retention has been expanded. This article aims to evaluate the effects of oral cyclosporin on chronic dietary modulation and acute excretion of renal excretion. The method is divided into 8-day chronic diet study and acute saline dilatation study in two parts, all conducted in Mongolian dogs of 16-21 kg with all dogs being paired and fed daily with constant food allowing free access to water. Experimental group 7, oral cyclosporine 20mg / kg / d; control group 6, cyclosporine daily excipients. Chronic Study: Determination of 24-hour sodium excretion, plasma renin activity (PRA), aldosterone (Aldo), endothelin (ET) and atrial natriuretic factor (ANF) before and 8 days after treatment. Acute Study: Intravenous infusion of 10% of body weight within 60 minutes