内化是生物大分子(包括细菌、病毒等)进入细胞内的膜泡转运过程。病毒内化是其复制、致病、抗原加工呈递和诱发机体免疫应答的前提,对研究病毒性疾病的发病机制具有重要意义。汉坦病毒主要通过受体介导的包涵素被覆小凹途径进入细胞。 Internalization is the transfer of biological macromolecules (including bacteria, viruses, etc.) into the cell vesicle. Viral internalization is a prerequisite for its replication, pathogenicity, antigen processing and presentation and induction of immune response to the body, and is of great significance for studying the pathogenesis of viral diseases. Hantaviruses enter the cell primarily through the receptor-mediated inclusion-helix-recessive pathway.