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本文用免疫组织化学 PAP法对正常 Wistar大鼠生后发育期间胃肠道生长抑素 ( SS)、5 -羟色胺( 5 - HT)及胃泌素 ( Gas)免疫反应 ( IR)细胞进行了定位研究和形态学观察。结果显示 ,SS- IR细胞于生后 1d已分布于胃肠各段。生后 1d- 4 5 d,胃窦部的 SS- IR细胞随生后龄的增长而逐渐增多 ,而其余肠道的 SS- IR细胞均以 18d为最多 ;5 - HT- IR细胞在生后发育期间可见于胃肠道各段 ,以十二指肠分布最为密集。生后发育期间的 5 - HT- IR细胞均以 18d数量最多 ;生后发育期间胃肠道的 Gas- IR细胞仅见于胃、十二指肠和空肠 ,以18d时胃窦和十二指肠的密度最大。胃肠道中 SS-、5 - HT、及 Gas- IR细胞的形态多种多样。 SS- HT- IR细胞除有突起伸至腔面外 ,尚有突起与邻与细胞接触。结果提示 ,三种 IR细胞在生后继续发生变化 ,表明各种内分泌激素在个体发育期间对机体的进一步发育起着重要作用
In this paper, the immunohistochemical PAP method was used to locate the gastrointestinal somatostatin (SS), serotonin (5 - HT) and gastrin (IR) immune responses in normal Wistar rats Research and morphological observation. The results showed that SS-IR cells were distributed in all segments of gastrointestinal tract 1d after birth. The number of SS-IR cells in gastric antrum increased gradually with the increase of postnatal age from 1d to 45d after birth, During development can be seen in various segments of the gastrointestinal tract, to the most intensive distribution of the duodenum. The number of 5 - HT - IR cells during postnatal development was the highest in 18 days. Gastrointestinal Gas - IR cells were only found in stomach, duodenum and jejunum during postnatal development. Gastric sinus and duodenum The density of the largest. Gastrointestinal SS-, 5 - HT, and Gas-IR cells in a variety of forms. In addition to the protrusion of SS-HT-IR cells protruding to the surface of the cavity, there are protrusions and neighbors to contact with the cells. The results suggest that the three IR cells continue to change after birth, suggesting that various endocrine hormones play an important role in the further development of the body during development