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采用大鼠双侧肾缺血1h与再灌注7天动物模型评价酸性成纤维细胞生长因子(aFGF)对肾急性缺血与再灌注损伤的治疗作用,并采用血浆尿素氮(BUN)、肌酐(Cr)变化以及组织病理学积分评价治疗效果。结果:在双侧肾再灌注损伤即刻从颈外静脉给予2.6μgaFGF能显著改善伤后1天的肾功能(aPGF)治疗组与生理盐水对照组的血浆BUN与Cr值分别为29.68±9.31mmol/L与62.96±22.26mmol/L,P<0.05;64.31±12.33μmol/L与100.43±31.72μmol/L,P<0.05),并且明显减轻肾组织水肿、间质浸润以及小管扩张与破坏。同时aFGP对恢复大同肾损伤后的体重损失有一定作用。aFGF这种显著的治疗效应可能来自于它的非促分裂激素样活性,即参与血管张力调节,影响细胞钙离子浓度平衡以及促进血浆纤维蛋白溶酶原前体(pA)分泌等。后期也可能与它促进组织细胞增殖与分化有关。
The animal model of bilateral renal ischemia 1h and reperfusion for 7 days was used to evaluate the therapeutic effect of aFGF on renal acute ischemia and reperfusion injury. Plasma urea nitrogen (BUN) and creatinine Cr) changes and histopathological scores to evaluate the therapeutic effect. Results: Immediate administration of 2.6 μ g FGF from the external jugular vein could significantly ameliorate renal function (aPGF) at 1 day after injury. The plasma BUN and Cr values in the treatment group and the saline control group were 29.68 ± 9.31 mmol / L and 62.96 ± 22.26 mmol / L, P <0.05; 64.31 ± 12.33 μmol / L and 100.43 ± 31.72 μmol / L, P < Significantly reduce renal edema, interstitial infiltration and tubule dilation and destruction. At the same time aFGP to restore the weight loss after kidney injury in Datong have a certain effect. A significant therapeutic effect of aFGF may come from its non-mitogenic activity, which is involved in the regulation of vascular tone, affecting the balance of cellular calcium concentration and promoting the secretion of plasma plasminogen precursor (pA). Late may also be related to its promotion of cell proliferation and differentiation.