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EDTA二钠是一个比较无毒的螯合剂,用来除去二价金属离子,可增加防腐剂和抗菌剂的作用,以及稳定抗氧化剂的作用。它的稳定性、适用性和低毒使它广泛应用于眼科和隐形眼镜的保护液中。本文用HPLC法定量测定多种眼药水和隐形眼镜保护液中的EDTA二钠,同时分离杂质氮基三乙酸。实验方法如下: 试剂和化学品:HPLC纯的乙腈和甲醇;经二次蒸馏、离子交换、活性炭过滤和倒渗透的水;氢氧化四丁铵(1M甲醇溶液) 仪器:色谱系统备有M6000双通道往
Disodium EDTA is a relatively non-toxic chelating agent used to remove divalent metal ions, can increase the role of preservatives and antibacterial agents, and stabilize the antioxidants. Its stability, suitability and low toxicity make it widely used in ophthalmic and contact lens protection solutions. This article by HPLC quantitative determination of a variety of eye drops and contact lens protection solution of disodium EDTA, while separation of impurities nitrilotriacetic acid. The experimental methods are as follows: Reagents and Chemicals: HPLC pure acetonitrile and methanol; water after secondary distillation, ion exchange, activated charcoal filtration and reverse osmosis; tetrabutylammonium hydroxide (1M methanol solution) Instrument: Chromatography system equipped with M6000 bis Channel to