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复方新诺明每片中含TMP 80mg和SMZ400mg。由于两药的抗菌谱基本相似,故并用后可得到较高的抑菌效果。有关本品的药动学特性及其临床意义已有较广泛的研究。一、复方新诺明的药动学特性吸收复方新诺明口服5分钟后,血中即可测得两药的浓度,1小时后血中到达有效治疗浓度,2～4小时后血中浓度达高峰,并能维持7小时以上,24小时后血中仍可测知其浓度。当口服一次剂量的TMP(200mg),1～2小时后,血药峰值可达2.19～2.5μg/ml,血中有效治疗浓度可维持12小时左右。而口服一次剂量的SMZ(800mg)
Cotrimoxazole tablets each containing TMP 80mg and SMZ400mg. As the antibacterial spectrum of the two drugs are similar, it can be used after the higher inhibitory effect. The pharmacokinetics of this product and its clinical significance has been more extensive study. First, the pharmacokinetics of cotrimoxazole compound Cotrimoxazole oral 5 minutes after oral administration, the concentration of the two drugs can be measured in the blood, 1 hour after the blood reached an effective therapeutic concentration, 2 to 4 hours after the blood concentration Up to the peak, and can maintain more than 7 hours, 24 hours after the blood can still be measured its concentration. When oral administration of a dose of TMP (200mg), 1 to 2 hours after the peak plasma up to 2.19 ~ 2.5μg / ml, the effective concentration of blood can be maintained for about 12 hours. Oral administration of a single dose of SMZ (800 mg)