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目的探究子宫内膜炎淋球菌基因突变与多重耐药性的关系。方法选择本院2014年1月至2014年12月收治的子宫内膜炎患者中分离出50株淋球菌菌株进行药敏试验以及mtr基因测序,记录并统计实验结果。结果不耐药菌株6株,单纯耐药菌株8株,多重耐药的菌株数量为36株。不耐药与单纯耐药的菌株数明显少于多重耐药的菌株数量。与标准菌株相比,不耐药与单纯耐药的菌株未见mtr基因改变,36株多重耐药菌株均可见mtr基因突变。结论淋球菌多重耐药性的发生率较高,淋球菌mtr基因突变在其产生多重耐药性的过程中具有重要作用。
Objective To investigate the relationship between the mutations of gonococcal endometritis and multidrug resistance. Methods Fifty Neisseria gonorrhoeae strains were isolated from patients with endometritis admitted from January 2014 to December 2014 in our hospital for susceptibility testing and mtr gene sequencing. The results of the experiment were recorded and statistically analyzed. Results 6 strains of drug-resistant strains, 8 strains of drug-resistant strains and 36 strains of multi-drug resistant strains. The number of drug-resistant and drug-resistant strains was significantly less than that of multi-drug resistant strains. Compared with the standard strains, there was no mtr gene mutation in the non-resistant and drug-resistant strains, and mtr gene mutation was observed in 36 multi-drug resistant strains. Conclusion The incidence of multiple drug resistance of Neisseria gonorrhoeae is high. The mutation of mtr gene of Neisseria gonorrhoeae plays an important role in the development of multiple drug resistance.