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目的 :观察实验性兔脑出血灶周围脑组织GFAP和S 10 0的变化 ,探讨脑出血继发性损害的机制。方法 :家兔 36只 ,分A、B、C、D 4组 ,B、C、D 3组采用自体血注射法制作脑出血模型 ,并分别于第 3d、7d、14d将兔处死。取出血周围脑组织作切片 ,用免疫组化法检测其GFAP和S 10 0的表达。结果 :A组 (对照组 )GFAP、S 10 0表达水平均较低 ,B、C、D组表达明显增高 (P <0 .0 5 ) ,且B、C、D 3组间比较差异亦有显著性 (P <0 .0 5 )。结论 :出血灶周围脑组织GFAP和S 10 0表达水平变化既是细胞组织损伤的表现 ,也是病变神经组织修复在分子水平的表现
Objective: To observe the changes of GFAP and S 10 0 in brain tissue around experimental intracerebral hemorrhage in rabbits and to explore the mechanism of secondary damage to cerebral hemorrhage. Methods: Thirty-six rabbits were divided into groups A, B, C, D 4, B, C, and D 3, and intracerebral hemorrhage was induced by autologous blood injection. The rabbits were killed on the 3rd, 7th and 14th day respectively. Peripheral blood was taken for slicing, and the expression of GFAP and S 10 0 was detected by immunohistochemistry. Results: The expression of GFAP and S 10 0 in group A (control group) was lower than that in group B, C and D (P <0.05), and there were also significant differences among groups B, C and D Significance (P <0.05). Conclusion: The changes of GFAP and S 10 0 expression in the brain tissue around the hemorrhage are not only the manifestation of cell injury, but also the expression of the nerve tissue repair at the molecular level