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目的:观察癫(痌)患者无发作期抗癫(痌)药物(AED)的应用情况,并探讨AED种类是否是脑电图异常的独立危险因素.方法:对205例癫(痌)无发作＞1年的患者进行回顾性分析,收集患者发病年龄、病程、家族史、病因、影像学检查、脑电图检查、AED种类等资料,利用统计学方法分析探讨AED种类对脑电图表现的影响.结果:本研究人组205例患者中,单药治疗为主(168例,82.0％),其中丙戊酸钠单药治疗最多(88例,52.4％).起病年龄越早、出生时有缺血缺氧史、发生过颅脑外伤以及进行过颅脑手术的患者脑电图异常率明显高于对照组.结论:大部分患者应用单一AED治疗即可控制癫(痌)发作,单药效果不佳者增加AED种数,仍可使部分患者受益.起病年龄越早、出生时有缺血缺氧史、颅脑外伤以及颅脑手术是脑电图异常的危险因素.“,”Objective:To observe the characteristics of antiepileptic drugs(AEDs)and analyze influencing factors of abnormal electroencephalography(EEG) in seizure-free patients.Methods:205 epileptic patients seizure-free for more than 1 year were analyzed by EEG so as to observe influencing factors of AED upon EEG.Results:Of 205 patients,168 patients(82.0％) took just one kind of AEDs including 88 patients(52.4 ％) who took valproic acid sodium(VPA).From multivariate analysis,the following were determined to influence the EEG(epileptiform discharge):the onset of younger age,the history of postpartum anoxic when born,cerebral trauma and the cerebral surgery.Conclusion:Most epileptic patients can control onset by taking one kind of AEDs.The epileptic history of postpartum anoxic,cerebral trauma,cerebral surgery and the onset of younger age are all the influencing factors of abnormal EEG presentation.