目的了解深圳市手足口病重症病例的流行病学特点和临床特征。方法对深圳市2010年61例手足口病重症病例进行个案调查,收集信息,建立数据库并进行统计分析。结果 5月是手足口病重症高发季节,男女比例为1.77:1,3岁以下患儿占80.33%,散居儿童占83.61%,临床表现以发热和皮疹为主,出现呕吐、嗜睡占67.21%,病原体为EV71占88.10%,从发病到首诊的时间间隔为1.98d。结论深圳市手足口病重症发病有季节性,以3岁以下散居儿童多发,应在流行季节针对重点人群开展综合防控措施。 Objective To understand the epidemiological characteristics and clinical features of HFMD in Shenzhen. Methods 61 cases of hand, foot and mouth disease in Shenzhen in 2010 were investigated by case studies. The information was collected and the database was established and analyzed statistically. Results May was a severe HFMD season with a ratio of 1.77: 80.33% of children under 1,3 years of age and 83.61% of children living in the community. The main clinical manifestations were fever and rash with vomiting and drowsiness accounting for 67.21% The pathogens accounted for 88.10% of EV71, from the onset to the first diagnosis of the time interval of 1.98d. Conclusions The incidence of HFMD in Shenzhen is seasonal. The incidence of diarrhea in children under 3 years of age is high. Comprehensive prevention and control measures should be implemented for key populations during the epidemic season.