目的：观察康乐斐（伪麻黄碱＋扑尔敏）抗家兔鼻充血作用，并分别与伪麻黄碱、扑尔敏比较其作用效果。方法：给家兔鼻腔滴入适量０．５％磷酸组胺，造成家兔鼻充血动物模型。测定给药后（康乐斐、伪麻黄碱、扑尔敏）家兔鼻腔滴磷酸组胺前后的温度变化。结果：康乐斐给药５０ｍｇ·ｋｇ１可拮抗家兔鼻腔滴磷酸组胺后鼻腔温度升高，但等剂量的伪麻黄碱则无此作用。结论：康乐斐有拮抗家兔鼻充血的作用，优于单用伪麻黄碱、扑尔敏 Objective: To observe the effect of Kanglefei (pseudoephedrine + chlorpheniramine) on nasal congestion in rabbits and compare their effects with pseudoephedrine and chlorpheniramine respectively. Methods: To the rabbit nose nasal drops of 0.5% histamine phosphate, resulting in rabbit nasal congestion model. The changes of temperature in nasal drops of histamine before and after administration were measured after administration (Kanglafei, pseudoephedrine and chlorpheniramine). Results: Kanglefei administration 50mg · kg1 can antagonize rabbit nasal drops of histamine after nasal temperature, but the equivalent dose of pseudoephedrine does not have this effect. CONCLUSION: Kanglefei has the effect of antagonizing nasal congestion in rabbits, which is better than that of pseudoephedrine alone, chlorpheniramine