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帕金森病(PD)是一种病因不清、机制未明的以中脑多巴胺能神经元减少为特征的退行性病变。神经细胞钙稳态失调在其发病中具有重要作用,而细胞内Ca2+浓度是由钙结合蛋白(CaBP)、Ca2+通道以及Ca2+泵共同维持。CaBP中的微清蛋白(PV)、维生素D依赖的钙结合蛋白28k(CB-D28k),和钙视网膜蛋白(CR)等缓冲蛋白具有缓冲Ca2+和神经保护作用。同时PD存在上述CaBP表达的减少,但它们之间究竟存在何种联系尚不清楚,现就近年来CaBP与PD关系的研究进展作以下综述。
Parkinson’s disease (PD) is a degenerative disease characterized by a diminished etiopathogenisis characterized by a reduced mechanism of dopaminergic neurons in the midbrain. Calcium homeostasis in neuronal cells plays an important role in its pathogenesis, whereas intracellular Ca2 + concentration is maintained by calcium-binding protein (CaBP), Ca2 + channels and Ca2 + pumps. Bovine serum albumin (PV), calcium-dependent vitamin C-dependent calcium-binding protein 28k (CB-D28k), and calcium retinal protein (CR) have buffering Ca2 + and neuroprotective effects. At the same time, there is a decrease in the expression of CaBP in PD mentioned above, but it is still not clear what kind of connection exists between them. The progress of CaBP and PD in recent years is summarized as follows.