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[目的]开发一条氟环唑中间体(Z)-2-(4-氟苯基)-1-(2-氯苯基)-3-溴丙烯的新工艺路线。[方法]以邻氯苯乙酸为起始原料,经酰氯化、酰基化、Wittig反应和溴化反应合成目标产物(Z)-2-(4-氟苯基)-1-(2-氯苯基)-3-溴丙烯。[结果]反应总收率为62.1%(以邻氯苯乙酸计),所有中间体及产物经1H NMR或MS对结构进行了表征。[结论]该工艺条件温和、操作简单,适合工业化生产。
[Objective] To develop a new route of epoxiconazole intermediate (Z) -2- (4-fluorophenyl) -1- (2-chlorophenyl) -3-bromopropene. [Method] The target product (Z) -2- (4-fluorophenyl) -1- (2-chlorobenzene) was synthesized by chlorination, acylation, Wittig reaction and bromination using o-chlorophenylacetic acid as the starting material Yl) -3-bromopropene. [Result] The total yield of the reaction was 62.1% (with o-chlorphenylacetic acid). All the intermediates and products were characterized by 1H NMR or MS. [Conclusion] The process conditions are mild, easy to operate and suitable for industrial production.