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目的：比较降纤酶与脉络宁治疗急性脑梗死的疗效。方法：经ＣＴ确诊脑梗死病人５０例，随机分为２组各２５例，２组在常规治疗（甘露醇、胞磷胆碱等）基础上，降纤酶组于治疗ｄ１～３给降纤酶１０ＩＵ，ｄ４～７给５ＩＵ，均溶于０．９％氯化钠注射液２５０ｍＬ中静脉滴注（静滴），ｑｄ，７ｄ为一个疗程。脉络宁组给脉络宁２０ｍＬ，溶于５％葡萄糖氯化钠注射液２５０ｍＬ中静滴，ｑｄ×７ｄ。结果：降纤酶组总有效率８８％，脉络宁组４４％，（Ｐ＜０．０１）。起病６ｈ内，２４ｈ内，及１ｗｋ内用药者，降纤酶组有效率依次为１００％，９２％及７５％；脉络宁组依次为６０％，４２％及３８％；２组均无不良反应。结论：降纤酶治疗急性脑梗死疗效优于脉络宁。
Objective: To compare the curative effect of defibrase and Mailuoning on acute cerebral infarction. Methods: Fifty patients with cerebral infarction confirmed by CT were randomly divided into two groups of 25 cases. On the basis of routine treatment (mannitol, citicoline, etc.), two groups were treated with defibrase group Enzyme 10IU, d4 ~ 7 to 5IU, were dissolved in 0.9% sodium chloride injection 250mL intravenous infusion (intravenous infusion), qd, 7d for a course of treatment. Mailuoning group Mailuoning 20mL, dissolved in 5% glucose and sodium chloride injection 250mL intravenous infusion, qd × 7d. Results: The total effective rate was 88% in defibrase group and 44% in Mailuoning group (P <0.01). Within 6h, 24h, and 1wk, the effective rates of defibrase were 100%, 92% and 75% respectively, while those in Mailuoning group were 60%, 42% and 38% reaction. Conclusion: Defibrase is superior to Mailuoning in the treatment of acute cerebral infarction.