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目的前瞻性探讨人群基线IL-6、NO水平与脑卒中发病的关联。方法对2 589名蒙古族居民进行基线调查,采集血清样本检测IL-6和NO,随访研究人群脑卒中发病和死亡情况。结果男性IL-6平均水平(7.93 ng/L)显著低于女性(8.54 ng/L),P<0.05;而男性NO平均水平(42.34μmol/L)显著高于女性(37.79μmol/L),P<0.05。平均随访9.2年,共发生脑卒中事件124例,其中缺血性脑卒中76例,出血性脑卒中46例,卒中分型不清2例。总的发病密度为519.11/10万人年,男性的各类脑卒中发病率均显著高于女性(P值均<0.05)。Cox比例风险模型分析结果显示,无论是否调整其他变量,IL-6和NO与各型脑卒中发病的风险比均无统计学意义。结论该人群具有较高的脑卒中发病率,且男性显著高于女性,基线IL-6和NO水平与缺血性脑卒中和出血性脑卒中事件均无关联。
Objective To prospectively investigate the correlation between baseline IL-6 and NO levels and the incidence of stroke in population. Methods A total of 2 589 Mongolian residents were investigated by baseline survey. Serum samples were collected to detect IL-6 and NO. The incidence and mortality of stroke in the population were investigated. Results The average level of IL-6 in males was significantly lower than that in females (7.93 ng / L, P <0.05), while the average level of NO in males (42.34 μmol / L) was significantly higher than that in females (37.79 μmol / L) P <0.05. The average follow-up of 9.2 years, a total of 124 cases of stroke, including 76 cases of ischemic stroke, hemorrhagic stroke in 46 cases, 2 cases of stroke was not identified. The total disease density was 519.11 / 100,000 person-years. The incidence of various types of stroke in men was significantly higher than that in women (all P <0.05). Cox proportional hazards model analysis showed no difference in the risk of IL-6 and NO with stroke incidence regardless of whether other variables were adjusted. Conclusions This population has a high incidence of stroke and is significantly higher in males than in females. Baseline IL-6 and NO levels are not associated with ischemic stroke and hemorrhagic stroke.