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目的探讨苦参素对慢性乙型肝炎血清细胞因子肿瘤坏死因子 α(TNF α)、白细胞介素 6(IL 6)、白细胞介素 8(IL 8)的影响作用。方法采用ELISA法对苦参素治疗前、治疗 3月后的轻度慢性肝炎、中度慢性肝炎、重度慢性肝炎患者血清中细胞因子TNF α、IL 6、IL 8活性进行测定 ,并设立对照组。结果苦参素对血清TNF α、IL 6、IL 8有明显抑制作用 ,各组治疗前、后及组间均有显著差异。结论在慢性乙型肝炎中苦参素具有调节细胞因子、减轻肝脏免疫损伤的作用
Objective To investigate the effects of oxymatrine on serum levels of TNFα, IL-6 and IL-8 in chronic hepatitis B patients. Methods Serum levels of TNFα, IL-6 and IL-8 in patients with mild chronic hepatitis, moderate chronic hepatitis and severe chronic hepatitis were measured by ELISA before treatment and after 3 months of treatment, and the control group . Results Oxymatrine had a significant inhibitory effect on serum TNFα, IL 6 and IL 8, and there were significant differences in each group before and after treatment. Conclusion Oxymatrine in chronic hepatitis B has the function of regulating cytokines and alleviating the immune damage of the liver