论文部分内容阅读
目的:探讨多囊卵巢综合征（PCOS）患者血清缺血修饰白蛋白（IMA）水平的变化，分析其与PCOS的相关性。方法:选取我院2017—2018年诊治的80例PCOS患者作为观察组，选择同期健康体检人员75例作为正常对照组，分别检测两组血清IMA水平、计算IMA指数，并比较两组体质量指数和生化指标，包括空腹血糖、空腹胰岛素、糖化血红蛋白、总胆固醇、三酰甘油、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、超敏C反应蛋白（hs-CRP），采用稳态模型评估法计算胰岛素抵抗指数（HOMA-IR），化学发光免疫分析法检测两组黄体生成素（LH）、卵泡刺激素（FSH）、睾酮（T）、雌二醇（En 2）、泌乳素（PRL），采用Pearson相关分析IMA与上述各项指标的相关性。n 结果:观察组和正常对照组IMA水平为（86.4 ± 10.5）、（73.6 ± 7.84）kU/L，差异有统计学意义（n P<0.05）。观察组和正常对照组IMA指数分别为93.21 ± 8.40、74.60 ± 6.52，差异有统计学意义（n P<0.05）。观察组空腹胰岛素[（14.90 ± 6.23）mU/L比（9.21 ± 1.5）mU/L]、HOMA-IR（3.64 ± 1.35比1.89 ± 0.91）、hs-CRP[（2.84 ± 0.73）mg/L比（0.81 ± 0.13）mg/L]、LH[（7.34 ± 2.65）mU/L比（4.50 ± 2.25）mU/L]、LH/FSH值（1.75 ± 0.62比0.90 ± 0.33）和T水平[（2.64 ± 1.25）ng/L比（1.26 ± 0.36）ng/L]显著高于正常对照组，差异有统计学意义（n P<0.05）。Pearson相关分析结果显示，血清IMA水平与T、HOMA-IR呈正相关（n r=0.47，n P<0.05；n r=0.58，n P 0.05）。n 结论:PCOS患者体内氧化应激标志物IMA水平增高，对PCOS患者检测血清IMA水平对疾病的治疗、评估有一定的临床意义。“,”Objective:To investigate serum ischemia modified albumin (IMA) levels in patients with polycystic ovary syndrome (PCOS) and to analyze its association with PCOS.Methods:Eighty patients(observation group) who received treatment in Tonglu Maternal and Child Health Hospital during 2017—2018, and 75 cases of healthy physical examination women (control group) were enrolled. The level of serum IMA was detected, and the IMA index was calculate. The levels of body mass index (BMI) and biochemical indexes such as fasting blood-glucose, fasting insulin, glycosylated hemoglobin, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterin, high-sensitivity C-reactive protein (hs-CRP) were compared. Homeostasis model assessment evaluated the insulin resistance index (HOMA-IR), and the levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), estradiol (En 2) and prolactin (PRL) were detected by chemiluminesent immunoassay assay. The relationship between serum IMA and the index above mentioned were analyzed by Pearson correlation.n Results:The level of IMA in observation group and control group was (86.4 ± 10.5) and (73.6 ± 7.84) kU/L, and there was significant difference (n P<0.05). The level of IMA index in observation group and control group was 93.21 ± 8.40, 74.60 ± 6.52, and there was significant difference (n P<0.05). The levels of serum fasting insulin, HOMA-IR, hs-CRP, LH, LH/FSH, T in observation group were significantly higher than those in control group: (14.90 ± 6.23) mU/L vs. (9.21 ± 1.5) mU/L, 3.64 ± 1.35 vs. 1.89 ± 0.91, (2.84 ± 0.73) mg/L vs. (0.81 ± 0.13) mg/L, (7.34 ± 2.65) mU/L vs. (4.50 ± 2.25) mU/L, 1.75 ± 0.62 vs. 0.90 ± 0.33, (2.64 ± 1.25) ng/L vs. (1.26 ± 0.36) ng/L, and there were significant differences (n P<0.05). In observation group, the level of IMA had positive correlation with the levels of T and HOMA-IR (n r=0.47, n P<0.05;n r=0.58, n P0.05).n Conclusions:The level of IMA in PCOS patients is increased, and detecting the level of IMA has important clinical significance in treatment and evaluation.