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目的:探讨术后肠内早期应用谷氨酰胺对剖宫产手术后产妇胃肠功能和免疫水平的影响,探索产妇饮食干预改善方案。方法:采用前瞻、随机、对照的方法选取120例经谷氨酰胺加强的饮食干预产妇为干预组,1∶1匹配未经谷氨酰胺加强的普通饮食干预产妇为对照组。记录两组产妇进食后胃肠耐受程度及干预后10日取外周血测定血清白蛋白和免疫球蛋白IgG、IgA、IgM及T淋巴细胞亚群CD4、CD8、CD4/CD8指标水平。结果:两组胃肠道耐受程度差异无统计学意义(P>0.05),免疫指标IgA、CD4、CD4/CD8差异有统计学意义(P<0.05)。结论:剖宫产术后产妇早期肠内应用谷氨酰胺可以改善免疫状态,提高产妇免疫水平,有利于产后恢复。
Objective: To investigate the effect of early postoperative enteral glutamine on the gastrointestinal function and immune status of postpartum women with cesarean section, and explore the improvement plan of maternal diet intervention. Methods: 120 prospective, randomized and controlled trials were conducted to select 120 maternal dietary supplements supplemented with glutamine as the intervention group. The 1: 1 matched maternal dietary supplementation without glutamine was used as the control group. The gastrointestinal tolerance of the two groups were recorded and the level of CD4, CD8 and CD4 / CD8 of serum albumin and immunoglobulin IgG, IgA, IgM and T lymphocyte subsets were measured at 10 days after intervention. Results: There was no significant difference in gastrointestinal tolerance between the two groups (P> 0.05). There were significant differences in the immunological indexes IgA, CD4, CD4 / CD8 (P <0.05). CONCLUSIONS: Early application of glutamine in pregnant women after cesarean delivery can improve the immune status, raise the level of maternal immunity and facilitate postpartum recovery.