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目的:分析复发性外阴阴道假丝酵母菌病(RVVC)的感染因素及药敏结果。方法:采用问卷调查分析125例RVVC患者的感染因素,并分离假丝酵母菌予以药敏分析。结果:RVVC患者的感染因素为年龄、文化程度、前次阴道炎治疗顺从性、性伴侣个数、性生活频率、阴道灌洗和非月经期使用护垫;158株假丝酵母菌中白假丝酵母菌117株(74.05%),热带假丝酵母菌30株(18.99%),光滑假丝酵母菌6株(3.80%),近平滑假丝酵母菌3株(1.90%)和克柔假丝酵母菌2株(1.26%);RVVC菌株对两性霉素和氟胞嘧啶的敏感性较高,而伏立康唑、氟康唑、伊曲康唑的耐药性较高。结论:针对RVVC患者的感染因素,选择药敏试验敏感的抗真菌药物,可有效防治RVVC。
Objective: To analyze the infection factors and drug susceptibility of recurrent vulvovaginal candidiasis (RVVC). Methods: The infection factors of 125 cases of RVVC patients were analyzed by questionnaire, and Candida albicans was isolated for drug susceptibility analysis. Results: The infection factors of RVVC patients were age, educational level, treatment compliance of last vaginitis, number of sexual partners, sex life frequency, vaginal lavage and non-menstrual period. 117 strains of filamentous yeast (74.05%), 30 strains of Candida tropicalis (18.99%), 6 strains of Candida glabrata (3.80%), 3 strains of Candida parapsilosis (1.90% 2 strains of filamentous yeast (1.26%), RVVC strains were more sensitive to amphotericin and flucytosine, while voriconazole, fluconazole and itraconazole were more resistant. Conclusion: According to the infection factors of RVVC patients, selecting anti-fungals sensitive to drug sensitivity test can effectively prevent and treat RVVC.