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目的探讨2型糖尿病患者波动性高血糖与糖尿病肾病的关系。方法选取2012年1月至2015年1月2型糖尿病患者100例,检测糖化血红蛋白(Hb A1c),并根据检测结果对患者进行分组,其中Hb A1c<9.0%者44例,Hb A1c≥9.0%者56例。根据患者的血糖变异系数(CV)再次对患者进行分组,包括血糖平稳组及血糖波动组,划分标准参照CV=0.29。测定空腹血糖值、Hb A1c、血脂各指标,观察各组糖尿病肾病的发生率,了解波动性高血糖与糖尿病肾病的关系。结果 CV值≥0.29组糖尿病肾病发病率均高于CV值<0.29组。四组以Hb A1c≥9.0%组糖尿病肾病发病率最高。结论 2型糖尿病患者中,波动性高血糖患者易诱发糖尿病肾病,需引起临床的高度重视,积极做好预防工作,降低并发症的发生,维护患者的健康。
Objective To investigate the relationship between hyperglycemia and diabetic nephropathy in type 2 diabetic patients. Methods One hundred patients with type 2 diabetes mellitus between January 2012 and January 2015 were enrolled in this study. Hb A1c was detected and grouped according to the test results. Among them, 44 cases were Hb A1c <9.0%, Hb A1c was 9.0% 56 cases. The patients were grouped again according to the patient’s CV (CV), including the stable glucose group and the blood glucose fluctuation group. The standard reference CV = 0.29. The fasting blood glucose, Hb A1c and lipids were measured to observe the incidence of diabetic nephropathy in each group and to understand the relationship between fluctuating hyperglycemia and diabetic nephropathy. Results The incidence of diabetic nephropathy with CV ≥0.29 was higher than that of CV <0.29. The incidence of diabetic nephropathy was highest in all four groups with Hb A1c≥9.0%. Conclusions Among patients with type 2 diabetes, patients with fluctuating hyperglycemia are apt to induce diabetic nephropathy. Therefore, it is necessary to pay close attention to the disease in clinic. Active prevention should be done to reduce the incidence of complications and maintain the health of patients.