在由序列医学切片图象重建三维细胞的过程中，对同一细胞在相邻切片中各剖面的配准是关键的一步。本文介绍一种借助转动惯量计算构造细胞剖面的等效椭圆并进一步对等效椭圆匹配以获得所需的几何变换进行剖面配准的自动方法。该方法已用于人体骨髓中巨核细胞的３－Ｄ配准并取得满意的效果。 In reconstructing three-dimensional cells from serial medical slice images, registration of the same cells in adjacent sections is a crucial step. This article presents an automated method for cross-sectional registration by calculating the equivalent ellipses that construct cell profiles with the help of moment of inertia and further matching the equivalent ellipses to obtain the required geometric transformations. This method has been used for 3-D registration of human megakaryocytes in human bone marrow with satisfactory results.