热休克蛋白gp96作为分子伴侣参与了肿瘤抗原向MHC-I类分子途径的递呈过程,并与抗原肽形成gp96-肽复合物激活CD8+T淋巴细胞,产生抗肿瘤的特异性免疫反应。此外,还能不依赖于抗原肽通过激活NF-κB信号转导,产生细胞因子和趋化因子,诱导树突状细胞成熟等多种作用而调节非特异性免疫反应。gp96-肽复合物疫苗为肿瘤的免疫治疗提供了新的思路。 As a chaperone, gp96, a heat shock protein, is involved in the presentation of tumor antigens to MHC class I molecules and forms gp96-peptide complexes with antigen peptides to activate CD8 + T lymphocytes and produce anti-tumor specific immune responses. In addition, the non-specific immune response can be regulated independently of the antigen peptide by activating NF-κB signal transduction, producing cytokines and chemokines and inducing maturation of dendritic cells. gp96-peptide complex vaccine provides a new idea for the immunotherapy of tumors.