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以氨三乙酸HNTA2-为主要配体,缬氨酸(valine)或亮氨酸(leucine)为次要配体在微酸性介质中合成了Ni(Ⅱ),Cu(Ⅱ),and Zn(Ⅱ)的三元配合物。用元素分析、热分析、FTIR,UV-Vis分光光度法,磁性测量和质谱法表征了合成的三元配合物。结果表明,三元配合物可在金属(M):氨三乙酸(HNTA)∶缬氨酸(valine)或亮氨酸(leucine)=1∶1∶1时制得,其分子结构为[M(HNTA)(valine)(H2O)2].1.5H2O and[M(HNTA)(leucine)(H2O)2].1.5H2O(其中M=Ni(Ⅱ)or Cu(Ⅱ))和H2[Zn(NTA)(valine)(H2O)]H2O。标题三元过渡金属配合物为八面体对称构型。同时研究了该三元配合物对大肠杆菌,金黄色葡萄球菌,白色念珠菌,黄曲霉菌(菌株从开罗大学理学院微分析中心获得)的抗菌活性。根据推荐的知名方法用标准的抗菌和抗真菌剂进行体外测试(in vitro)以评估我们的新制备的配合物对细菌和真菌物种的生长抑制活性。
The Ni (Ⅱ), Cu (Ⅱ), and Zn (Ⅱ) complexes were synthesized with nitrilotriacetic acid HNTA2- as the main ligand and valine or leucine as the secondary ligand in a slightly acidic medium. ) Ternary complex. The synthesized ternary complexes were characterized by elemental analysis, thermal analysis, FTIR, UV-Vis spectrophotometry, magnetic measurement and mass spectrometry. The results show that the ternary complex can be prepared when the metal (M): nitrilotriacetic acid: valine or leucine = 1: 1: 1 and the molecular structure is [M (HNTA) (H2O) 2] 1.5H2O and [M (HNTA) (leucine) (H2O) 2] 1.5H2O with M = Ni (Ⅱ) or Cu NTA) (valine) (H2O)] H2O. The title ternary transition metal complex is an octahedral symmetrical configuration. The antibacterial activity of the ternary complex against Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus flavus (strain obtained from the Center for Micronanalysis of Faculty of Science, Cairo University) was also studied. In vitro tests were performed with standard antibacterial and antifungal agents according to the well-known recommended method to assess the growth inhibitory activity of our newly prepared complexes on bacterial and fungal species.