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目的:观察异甘草酸镁联合恩替卡韦分散片治疗慢性乙型肝炎的疗效分析。方法:将200例慢性乙型肝炎患者随机分成两组,对照组使用恩替卡韦分散片进行治疗,实验组用异甘草酸镁和恩替卡韦分散片联合治疗。观察治疗前后两组在乙型肝炎病毒学指标HBV-DNA、血清学检测指标乙肝“两对半”、肝细胞损伤程度的检测:包括丙氨酸氨基转移酶(ALJ)和天门冬氨酸氨基转移酶(AST)的变化。结果:实验组与对照组相比,有较高的肝功能好转程度。HBV-DNA转阴率,HbeAg转阴率差异有统计学意义。结论:联合应用异甘草酸镁和恩替卡韦分散片治疗慢性乙型肝炎的效果显著优于单纯使用恩替卡韦分散片。
Objective: To observe the curative effect of magnesium glycyrrhizinate combined with entecavir dispersible tablets on chronic hepatitis B. Methods: 200 patients with chronic hepatitis B were randomly divided into two groups, the control group treated with entecavir dispersible tablets, the experimental group with magnesium glycyrrhizinate and entecavir dispersible tablets combined treatment. The levels of hepatitis B virus (HBV) DNA, serological markers Hepatitis B, “two and a half”, and the degree of hepatocellular injury were detected in both groups before and after treatment: including alanine aminotransferase (ALJ) and aspartate Changes in acid aminotransferase (AST). Results: The experimental group compared with the control group, have a higher degree of improvement of liver function. HBV-DNA negative rate, HbeAg negative rate difference was statistically significant. Conclusion: The combination of magnesium isoglycyrrhizinate and entecavir dispersible tablets in the treatment of chronic hepatitis B was significantly better than the simple use of entecavir dispersible tablets.