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目的：探讨血管紧张素Ⅱ受体拮抗剂ｃｏｚａａｒ（商品名科素亚）抗心力衰竭疗效及对充血性心力衰竭患者血浆部分神经内分泌激素的影响。方法：３５ 例充血性心力衰竭患者服用ｃｏｚａａｒ ２５ ｍ ｇ／ｄ～５０ｍ ｇ／ｄ 治疗１２ 周，观察其治疗前后血浆肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡｎｇⅡ）、去甲肾上腺素（ＮＥ）、肾上腺素（Ｅ）、内皮素（ＥＴ）、一氧化氮（ＮＯ） 水平及治疗前后心功能改变情况。结果：ｃｏｚａａｒ 治疗１２ 周后心功能得到明显改善，血浆ＰＲＡ、ＡｎｇⅡ、ＮＥ、ＥＴ水平均显著下降，ＮＯ水平升高。结论：血管紧张素Ⅱ拮抗剂不仅能抑制肾素一血管紧张素活性，还能抑制交感神经系统活性，调节内皮细胞舒缩功能，改善心功能
Objective: To investigate the therapeutic effect of angiotensin Ⅱ receptor antagonist cozaar (Coxsackievir) against heart failure and its effect on plasma neuroendocrine hormones in patients with congestive heart failure. Methods: 35 patients with congestive heart failure were treated with cozaar at a dose of 25 mg / d ~ 50 mg / d for 12 weeks. The changes of plasma renin activity (PRA), angiotensin Ⅱ (AngⅡ), norepinephrine NE), epinephrine (E), endothelin (ET), nitric oxide (NO) and the changes of cardiac function before and after treatment. Results: After 12 weeks of treatment with cozaar, heart function was significantly improved. Plasma PRA, AngⅡ, NE, ET levels were significantly decreased, NO levels increased. Conclusion: Angiotensin Ⅱ antagonists not only inhibit renin-angiotensin system activity but also inhibit sympathetic nervous system activity, regulate endothelial function and improve cardiac function