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目的:比较黄体酮阴道缓释凝胶(雪诺同)和黄体酮软胶囊(安琪坦)经阴道给药作为体外受精-胚胎移植(IVF-ET)/卵泡浆内单精子注射授精(ICSI)后常规黄体支持用药的效果。方法:回顾性分析河南省人民医院2012年6月~2012年12月常规长方案新鲜移植周期共591个周期,按照黄体支持使用药物的不同,随机分为雪诺同组和安琪坦组,其中雪诺同组共228个周期,安琪坦组共363个周期,比较两种药物在IVF黄体支持中的有效性。结果:两组间临床妊娠率、种植率、活产率比较,雪诺同组(61.84%,45.39%,52.63%)均高于安琪坦组(60.05%,43.29%,49.59%);两组早期流产率、异位妊娠率比较,雪诺同组(8.51%,0)低于安琪坦组(10.09%,0.92%),但差异均无统计学意义(P>0.05)。结论:使用雪诺同作为IVF/ICSI-ET后黄体支持常规用药较安琪坦获得更好的临床效果,有减少早期流产的可能。
OBJECTIVE: To compare the effects of vaginal administration of progesterone vaginal sustained-release gel (Snow Connaught) and progesterone soft capsule (Angelant) vaginal administration as in vitro fertilization-embryo transfer (IVF-ET) / intracytoplasmic sperm injection ) After conventional luteal support medication effect. Methods: A total of 591 cycles of routine long-term transplantation were retrospectively analyzed in Henan Provincial People’s Hospital from June 2012 to December 2012. According to the different drugs supported by corpus luteum, they were randomly divided into three groups: Among them, there were 228 cycles in the same group and 363 cycles in the Angel group, comparing the effectiveness of the two drugs in IVF luteal support. Results: The clinical pregnancy rate, implantation rate and live birth rate of the two groups were significantly higher than those of Angel group (61.05%, 43.29% and 49.59%, respectively) in the two groups (61.84%, 45.39%, 52.63% The rate of early miscarriage and ectopic pregnancy in group Soxhlet group (8.51%, 0) was lower than that in Angel group (10.09%, 0.92%), but the difference was not statistically significant (P> 0.05). Conclusion: The use of Snow Connaught as IVF / ICSI-ET after corpus luteum support conventional medication to get better clinical results, there is the possibility of reducing the early miscarriage.