Huntington\'s disease (HD) is an inherited autosomal dominant neurodegenerative disease characterized by progressive motor deficits,cognitive decline,and psychiatric symptoms.It is caused by a pathological expansion of CAG trinucleotide repeats in exon 1 of the HD gene,resulting in the translation of a mutant form of huntingtin protein (mutant Htt) with an expanded polyglutamine domain in the N-terminal region [1].