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本文以单独或联合应用H_1、H_2受体阻滞剂探讨实验性烧伤性休克的家兔在血流动力学、微循环、肺组织病理检查和动物存活时间等方面所产生的各种效应,评价H_1、H_2受体阻滞剂对重症烧伤性休克的治疗价值并探讨其机理。实验提示H_2受体阻滞剂(甲氰咪胍100mg/kg)对烧伤性休克动物生存时间、血流动力学等有明显的改善,并减轻了烫伤热力对肺的损伤反应:H_1受体阻滞剂(盐酸苯海拉明4mg/kg)与对照组比较无显著意义。
In this paper, H 1 and H 2 blockers alone or in combination were used to explore various effects of haemodynamics, microcirculation, pathological examination of lung tissue and animal survival time in rabbits with experimental burn shock. H_1, H_2 receptor blockers in the treatment of severe burn shock and explore its mechanism. Experimental results suggest that H_2 receptor blocker (cimetidine 100mg / kg) significantly improves the survival time and hemodynamics of burn shock animals, and reduces the damage of lung injury induced by scald heat: H_1 receptor blocker Delayed agent (diphenhydramine hydrochloride 4mg / kg) compared with the control group was not significant.