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目的 探索肿瘤前期 (I、II期 )蕈样肉芽肿 (MF)临床诊断特点及治疗方案。方法 对近 2年来收治的 6例肿瘤前期MF患者进行临床分析 ,并总结在诊治肿瘤前期MF方面的经验。结果 结果显示 ,老年男性、顽固性瘙痒、鳞屑性红斑、单个不规则浸润性斑块是诊断肿瘤前期MF的重要提示。采用氮芥溶液和 (或 )PUVA并合用激素局部治疗 ,是治疗肿瘤前期MF安全有效而副作用少的方法。结论 肿瘤前期MF临床表现虽复杂多变 ,但仍有特征性的表现 ,局部治疗辅以免疫调节剂仍是治疗的首选。
Objective To explore the clinical diagnostic features and treatment of mycosis fungoides (MF) in pre-neoplastic (stages I and II). Methods Six cases of MF patients with precancerous lesions treated in the past 2 years were analyzed clinically and their experience in the diagnosis and treatment of MF at the early stage of tumor was summarized. Results The results showed that older men, intractable pruritus, erythematous scales, and single irregular infiltrative plaques are important tips for the diagnosis of MF at the preneoplastic stage. The use of nitrogen mustard solution and (or) PUVA in combination with topical hormonal therapy is a safe and effective treatment of MF in the preneoplastic phase with few side effects. Conclusion Although the clinical manifestations of MF in precancerous lesions are complex and changeable, they still have characteristic features. Local treatment supplemented with immunomodulators is still the first choice for treatment.