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目的探讨阴道唾液酸酶和血清细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)水平联检在胎膜早破中的临床意义及两者之间的关系。方法采用比色法对阴道分泌物进行阴道唾液酸酶检测和酶联免疫方法检测158例足月前胎膜早破、96例足月胎膜早破孕妇血清ICAM-1的表达情况,选取正常足月孕妇80例为对照组,观察结果并进行统计学处理。结果胎膜早破组孕妇阴道唾液酸酶检测阳性率及血清中ICAM-1水平均明显高于正常足月孕妇组,统计学分析显示两组间差异有统计学意义(P<0.05);而足月前与足月胎膜早破孕妇阴道唾液酸酶检测阳性率及血清ICAM-1比较差异无统计学意义(P>0.05)。结论联合阴道唾液酸酶和血清ICAM-1检测在临床预测胎膜早破有一定的应用价值。
Objective To investigate the clinical significance of vaginal sialidase and intercellular adhesion molecule-1 (ICAM-1) level in premature rupture of membranes and the relationship between the two. Methods The vaginal sialidase and enzyme-linked immunosorbent assay were used to detect the expression of ICAM-1 in 158 preterm premature rupture of membranes and 96 full term premature rupture of membranes in pregnant women with colorimetric method. 80 full-term pregnant women as the control group, the observation results and statistical analysis. Results The positive rate of vaginal sialidase in pregnant women with premature rupture of membranes and ICAM-1 levels in serum were significantly higher than those in normal term pregnant women. The statistical analysis showed that the difference between the two groups was statistically significant (P <0.05) There was no significant difference in the positive rates of vaginal sialidase and serum ICAM-1 between pre-term and full-term premature rupture of membranes (P> 0.05). Conclusion Combined vaginal sialidase and serum ICAM-1 detection in the clinical prediction of premature rupture of membranes has a certain value.