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目的探讨抗结核药物致肝功能损伤的临床特点和治疗经验。方法对2008年1月至2009年1月收治的的肺结核患者抗结核治疗后出现肝损伤的216例患者进行回顾性分析。结果抗结核药所致肝损伤多见于具有危险因素的患者,多发生于用药的第1～8周。结论对抗结核药致肝损伤的早期诊断和及时合理的治疗,可以使患者的肝功能恢复正常,帮助患者顺利完成抗结核治疗疗程。
Objective To investigate the clinical features and treatment experience of anti-TB drug-induced liver injury. Methods A retrospective analysis was performed on 216 patients with liver damage after anti-TB treatment of tuberculosis patients admitted from January 2008 to January 2009. Results Anti-TB drug-induced liver injury more common in patients with risk factors, occurred in the first 1 to 8 weeks of medication. Conclusion Early diagnosis and timely and reasonable treatment of liver injury caused by anti-tuberculosis drugs can restore the normal liver function of patients and help patients to complete the anti-TB treatment successfully.