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目的：观察草酸艾司西酞普兰联合小剂量奥氮平治疗老年期抑郁症的临床疗效。方法选取2013年6月-2014年7月老年科收治的住院或门诊患者60例，随机分为试验组和对照组各30例。试验组予草酸艾司西酞普兰合并奥氮平治疗，对照组仅予草酸艾司西酞普兰治疗，治疗共进行8周，采用汉密顿抑郁量表（HAMD），不良反应量表（TESS）进行测评。结果试验组显效率83.00%明显高于对照组的73.00%，差异有统计学意义（P ＜0.05）；2组治疗后 HAMD 评分比较差异有统计学意义（P ＜0.05）。试验组嗜睡、体质量增加不良反应发生人数较对照组高，比较差异有统计学意义（P ＜0.05）；而2组口干、恶心、心动过速等不良反应比较差异无统计学意义（P ＞0.05）。结论老年抑郁症患者可以考虑草酸艾司西酞普兰合并小剂量奥氮平治疗，疗效显著。值得临床推广运用。“,”Objective To observe the clinical curative effect of escitalopram combined with small dose of olanzapine in the treatment of senile depression. Methods From June 2013 to July 2014,60 patients with senile depression were random-ly divided into experimental group and control group,each of 30 cases. The experimental group was given escitalopram com-bined with small dose of olanzapine for treatment,while the control group was only given escitalopram for treatment. Both groups were treated for 8 weeks. The clinical effect was evaluated by using Hamilton depression scale(HAMD),adverse reaction scale (TESS). Results The effective rate of the experimental group was 83. 00% ,which was higher than 73. 00% of the control group,the difference was statistically significant(P < 0. 05). The difference of HAMD was statistically significant between 2 groups(P < 0. 05). The number differences of Sleepiness,weight gain were statistically significant between 2 groups(P 0. 05). Conclusion The curative effect of escitalopram combined with small dose of olanzapine in the treatment of senile depression is remarkable, which is worthy of clinical application.