目的探讨纳米炭淋巴结示踪剂在分化型甲状腺癌Ⅵ区淋巴结清扫术中的应用效果。方法 80例分化型甲状腺癌患者,随机分为纳米炭组和对照组各40例;纳米炭组术中向患侧甲状腺内注入纳米炭混悬注射液,对照组则不予注射,均规范行原发灶处理及Ⅵ区淋巴结清扫;比较两组淋巴结检出数量、转移情况以及甲状旁腺意外切除率。结果纳米炭组平均每例检出淋巴结6.7枚(淋巴结黑染率为69.89%),对照组为3.6枚,P<0.05;纳米炭组共检出直径<2 mm淋巴结95枚(35.32%),对照组为30枚(22.90%),P<0.01。纳米炭组和对照组淋巴结转移率分别为55%、50%,淋巴结转移度分别为21.19%、24.31%,P均>0.05;黑染与未黑染的淋巴结转移率分别为20.74%、22.22%,P>0.05;纳米炭组病理检查标本中未发现甲状旁腺,对照组检出3枚甲状旁腺,但P>0.05。结论纳米炭淋巴示踪剂染色效果良好,提高了淋巴结检出数量,从而能更真实准确地反映Ⅵ区淋巴结状态,提高了肿瘤临床分期的准确性,为合理制定进一步手术方案及后续综合治疗提供帮助。 Objective To investigate the effect of nanocarbon lymph node tracer in differentiating type Ⅵ lymph node dissection of thyroid cancer. Methods Eighty patients with differentiated thyroid cancer were randomly divided into two groups: control group (n = 20) and control group (n = 40). Nanocarbon group was injected intraperitoneally Primary treatment and Ⅵ lymph node dissection; compared the number of lymph nodes in the two groups, metastasis and accidental resection rate of parathyroid. Results There were 6.7 lymph nodes (69.89%) in the nanocarbon group and 3.6 in the control group (P <0.05). A total of 95 lymph nodes (35.32%) were detected in the nanocarbon group, The control group was 30 (22.90%), P <0.01. The rates of lymph node metastasis were 55%, 50% and lymph node metastasis in the nanocarbon group and control group were 21.19% and 24.31%, respectively, all P> 0.05. The rates of lymph node metastasis were 20.74% and 22.22% , P> 0.05; no parathyroid gland was found in the pathological examination of the nanocarbon group, and 3 parathyroid glands were detected in the control group, but P> 0.05. Conclusion The nanocarrier tracer has a good staining effect and increases the number of lymph node detection, which can reflect the status of Ⅵ lymph node more accurately and accurately, and improve the accuracy of clinical staging. It is necessary to provide a reasonable solution for further surgical treatment and follow-up comprehensive treatment help.