目的:探讨CYP11B2和CYP11B1基因多态性及其他因素与醛固酮瘤术后持续性高血压的相关性。方法:提取81例肾上腺醛固酮瘤患者外周血DNA,采用TaqMan探针技术及两对独立PCR反应检测基因多态性位点;收集患者临床资料及随访信息,分析比较术后血压恢复组与未恢复组的数据,用logistic回归分析影响醛固酮瘤术后血压恢复不佳的危险因素。结果:61.7%患者术后血压恢复正常,38.3%患者术后仍有持续性高血压。CYP11B2和CYP11B1基因多态性在血压恢复组与未恢复组的分布差异无统计学意义。血压恢复组患者较未恢复组年龄小,体重指数低,高血压病程短,术前使用降压药数量少,术前对螺内酯治疗更敏感。多元logistic回归分析显示术前控制血压用药量≥2种(OR 6.65,95%CI 1.43~30.81,P=0.016)、术前对螺内酯治疗不敏感(OR 4.39,95%CI 1.34~14.29,P=0.015)是术后血压恢复不佳的独立危险因素。结论:CYP11B2和CYP11B1基因多态性与醛固酮瘤术后血压恢复无相关性;术前对螺内酯治疗不敏感和术前降压药用量≥2种是醛固酮瘤术后血压恢复不佳的独立危险因素,对临床判断预后提供了一定的依据,及早诊断和治疗可以使醛固酮瘤患者有更大益处。 Objective: To investigate the association between CYP11B2 and CYP11B1 gene polymorphism and other factors and persistent hypertension after aldosteronoma. Methods: 81 cases of adrenal aldosteronoma patients with peripheral blood DNA extraction, using TaqMan probe technology and two pairs of independent PCR reaction detection of genetic polymorphisms; clinical data and follow-up information were collected, analysis of postoperative blood pressure recovery group and did not recover Group data, logistic regression analysis of aldosterone tumor affecting postoperative blood pressure recovery poor risk factors. Results: Postoperative blood pressure returned to normal in 61.7% of patients, and persistent hypertension remained in 38.3% of patients. There was no significant difference in the distribution of CYP11B2 and CYP11B1 gene polymorphisms between BPH patients and non-BPH patients. Compared with the non-recovery group, patients in the recovery group had younger age, lower body mass index, shorter duration of hypertension, less preoperative use of antihypertensive drugs and more preoperative spironolactone treatment. Multivariate logistic regression analysis showed that preoperative control of blood pressure was ≥2 (OR 6.65, 95% CI 1.43-30.81, P = 0.016). Preoperative spironolactone treatment was not sensitive (OR 4.39, 95% CI 1.34-14.29, P = 0.015) is an independent risk factor for postoperative poor recovery of blood pressure. CONCLUSION: There is no correlation between CYP11B2 and CYP11B1 gene polymorphism and postoperative blood pressure recovery in aldosterone neoplasms. Preoperative non-responsiveness to spironolactone treatment and preoperative antihypertensive dosage ≥2 are independent risk factors for poor recovery of aldosterone tumors postoperatively Factors that provide a basis for the clinical judgment of prognosis, early diagnosis and treatment can make patients with aldosterone tumors have greater benefits.